مجله دیابت و متابولیسم ایران
سال پانزدهم شماره 5 (پیاپی 68، خرداد و تیر 1395)

In the event of damage to the skin, the epidermis of which goes to the disintegration of the body, is a wound that is common in diabetics. The purpose of this study was to evaluate microscopic effects of Aqueous extract of curcumin on wound healing in diabetic male rats.
In this study 48 male Wistar rats were divided into 4 groups (control, sham, experimental, empirical two) were tested. The extra pawn injured area of 3 cm to the left of the spine created. Wound healing was examined microscopic.
The streptozocin diabetic wound healing compared to the control group later showed and wound healing in experimental groups treated with Aqueous extract of curcumin was faster than the control group.
The results showed that the Aqueous extract of curcumin skin accelerates wound healing in normal and diabetic samples.

Myokines released from skeletal muscle have multiple metabolic and hypertrophic effects. On the other hand, one of proposed pathways for effects of exercise training on metabolic diseases is calcineurin signaling pathway. With considering to relation between interleukin-6 (IL-6) and calcineurin, the purpose of this study was to investigate whether the resistance training has an effect on mRNA expression of IL-6 myokine and regulator of calcineurin 1(RCAN-1) in skeletal muscle of diabetic rats.
Thirty two Rats randomly were divided into the control, training, diabetic control and diabetic training groups. Diabetes induced by streptozotocin (STZ). Training groups performed the 17 sessions of resistance training. The IL-6 and RCAN-1 mRNA expression were measured in Soleus skeletal muscle using the Real-time PCR method. Two-way analysis variance was used for statistical analysis. Also, Statistical significance was set at p The results of this study showed that the mRNA expression of RCAN-1 was increased with resistance training in skeletal muscle of training groups (P With considering to our results, resistance training with direct effects on skeletal muscle could regulate calcineurin pathway in diabetes and concurrent increase in expression of IL-6 myokine. It seems that activation of this signaling pathway with resistance training could maintain skeletal muscle mass in diabetes.

Insulin resistance and progressive β-cells failure are the key factors in type 2 diabetes mellitus (T2DM) pathogenesis. Many studies support a primary role of RBP4 in insulin resistance and suggest that genetic variations which alter the expression level of RBP4 might influence the risk of T2DM and its complications. Diabetic foot is one of the main complications of diabetes leading to disability and hospitalization. In addition, it reduces quality of life and imposes great cost to patients. The purpose of this study was to evaluate the correlation between two single nucleotide polymorphisms (rs10882273 and rs10882283) of RBP4 genes with diabetic foot ulcer in order to identify a biomarker for prediction of diabetic foot ulcer.
This is a case-control study. Two single nucleotide polymorphisms of RBP4 genes were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 133 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.
The Chi-square test revealed no significant difference in frequency of TT, CC and TC alleles of rsl0882273 between case and control groups (P=0.414). Also, Comparison of AA, CC and AC alleles of rsl0882283 in both groups did not show significant difference (P=0.85).
According to this study, there is no relationship between two single nucleotide polymorphisms of RBP4 genes (rs10882273 and rs10882283) with diabetic foot ulcer in type2 diabetes patients.

The purpose of this study is to the comparison of the effect of 12 weeks of sprint training and concurrent aerobic and strength training on high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and insulin resistance in women with diabetes mellitus (T2DM)
52 overweight female type 2 diabetic patients (age; 45-60 years old and fasting blood glucose ≥ 126 mg/dl (7.0 mmol/l)) were assessed for eligibility. Participants were assigned to intense interval training group (N=17), concurrent resistance- endurance training group (N=17) and control group (N=18). The combined strength-endurance group did 12 weeks, three sessions per week endurance training with 60 % of maximal heart rate and two session resistance training with 70 % 1-RM. Intense interval training group did three session/week of 4-10 repetition of all out 30s Wingate on ergometer were included 10 weeks of concurrent resistance- endurance training and intense interval training.
The results showed that following sprint training, there were significant changes in hs-CRP (p Intense sprint training compare to concurrent strength-endurance training can have better inflammatory status for patients with type 2diabete.

Type 2 diabetes mellitus is a major general health problem that causes widespread effects on the individual and social functions. The purpose of this study was to investigate the relationship between health literacy and general health in type 2 diabetic patients.
This cross-sectional study was done on 200 patients referred to the Diabetes Research Center, Tehran University of Medical Sciences in 1392. Data were collected using three questionnaires: demographic characteristics, health literacy (TOHFLA), general health (GHQ28 . Data analyses were done by using descriptive statistical tests, frequency distribution tables and tests (test t, ANOVA) using SPSS (Version 16).
More than half of participants (58%) didnt have adequate health literacy and their general health was average (average: 53/7 ± 58/48). There was a significant correlation between health literacy and public health (p: 0.007, r:-0.191). Health Literacy was statistically significant with three aspect of general health, anxiety and sleep disorders (p: 0/0029, -0/154), social functioning (p: 0/013, r:-0/176) and depression (p: 0/002, r:-0/218).
In general, chronic diseases, including diabetes type 2 has clinical, social and psychological problems, which leads to mental and physical limitations in these people. This study showed that inadequate health literacy and public health are common problems, which indicate that diabetic patients need more education to improve their level of health literacy and general health.

Noticing to high prevalence and complications rates of Diabetes Mellitus and its effect on quality of life, and also considering low quality of life, can cause low self-care and increase complications among these patients. The goal of this study is comparing the effect of multimedia education with live successful experiments on quality of life in type 2 diabetic patients.
This is a semi experimental study. First 160 type 2 diabetic patients were selected First 160 type 2 diabetic patients were selected and then randomly allocated into two tests and one control groups. Research tools were self-statement demographic and WHO-QOL Brief questionnaires which were completed before interventions. For first test group educational classes with multimedia method (group discussion, educational film and slides) were hold in 5 sessions each in 45 minutes. For second test group education was based on narrating of live successful experiments by the patients who controlled their diabetes and answer to questions of the patients. After 3 month WHO-QOL Brief questionnaires which were completed again. All data were analyzed with SPSS version 20 software.
There was no significant difference in means of quality of life among three groups before interventions (p= 0.194). There was significant difference in means of quality of life among three groups after interventions (p= 0.04). There were significant differences between the means of quality of life in first test group (P≤0.001) and second test group (P≤0.001) before and after interventions.
Qualities Of Life in first and second test group were increased more than control one.

In recent years, waist and hip circumference measurements simultaneously used as anthropometric factors to determine the prevalence of overweight and obesity in adults, in addition to Body Mass Index. Some studies have confirmed the relationship between the above mentioned factors and the hematological parameters of cardiometabolic disorders. This study aimed to determine the association between anthropometric factors and hematological factors in 25-60 years old couples of Babol, Mazandaran.
This cross-sectional descriptive study was conducted in spring 2014, on research population of 25-60 year old couples who were selected by random cluster. Data collected through a researcher-made questionnaire containing about demographic variables, underlying factors, dependent variables; its validity and reliability were confirmed. The collected data were analyzed by SPSS18 software.
Men’s BMI had significant direct relationship with systolic and diastolic blood pressure, fasting blood sugar, cholesterol and triglycerides (p The results showed that increased BMI and WHR in couples, increases the amount of cardiometabolic serum biomarkers and may directly and indirectly cause the risk of chronic diseases.